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IGF2 Antibody

SKU : BHA10557315

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA011088KA01HU
Alternative Names	IGF2; IGF-II; PP9974; C11orf43
Categories	Primary Antibodies
Description	This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5 region overlaps the INS gene and the 3 region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Hgnc	5466
Host	Rabbit
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Silver-Russell syndrome (SRS); Growth restriction, severe, with distinctive facies (GRDF)
Isotype	IgG
Mgi	96434
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5 region overlaps the INS gene and the 3 region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Secreted

Rgd	2870
Target Details	This gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3 region and to the upstream INS gene at the 5 region. Alternatively spliced transcript variants, encoding either the same or different isoform, have been found for this gene.
Uniprot	P01344
Database Links	HGNC:5466 OMIM:147470 KEGG:hsa:3481 STRING:9606.ENSP00000391826 UniGene:Hs.272259
Function	The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable).
Pathway	MAPK signaling pathway PI3K-Akt signaling pathway Ras signaling pathway
Protein Families	Insulin family
Research Area	Metabolism
Tissue Specificity	Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:2000

Tested Application

ELISA,WB;WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557315	CSB-PA011088KA01HU	100ul	$398		Add to Cart

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