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Home / Primary Antibodies / Polyclonal Antibodies

IFNAR1 antibody

SKU : BHA10804141

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Mfr.No.	FNab04147
Alternative Names	IFNAR
Background	The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
Host	Rabbit
Immunogen	interferon (alpha, beta and omega) receptor 1
Isotype	IgG
Molecular Weight	70 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	IFNAR

Uniprot	P17181
Gene Id	3454
Research Area	Immunology, Cardiovascular, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, FC
Description	ELISA ; WB ; FC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04147.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804141	FNab04147	100ug	$280		Add to Cart

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