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Home / Antibodies

IFNA1 Antibody

SKU : BHA10557119

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA365592KA01HU
Alternative Names	IFN-α;IFNA1;IFL;IFN;IFN-ALPHA;IFNA13;MGC138207;MGC138505;MGC138507
Categories	Primary Antibodies
Description	Interferon-α1 is a member of the Type I IFN family best known for their antiviral activity. Most nucleated cells produce one or more Type I IFNs in response to viral infection. Secreted Type I IFN then induces viral protective responses in neighboring non-infected cells. Type I IFNs also enhance virus-induced apoptosis. Other IFN-α1 activities include enhancement of dendritic cell maturation and cytotoxic T cell activity. IFN-α1 binds to the IFN-αR1 and IFN-αR2 heterodimer. Intracellular signaling through the Jak/Stat pathway is best characterized. However, the PI3K, ERK, and p38 kinase pathways are also involved. The antiviral activities of the IFNs have led to their use in treating viral infections. Type I IFNs also appear to have an integral role in several autoimmune diseases.
Host	Rabbit
Immunogen	Recombinant protein of Human IFN-α
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Interferon-α1 is a member of the Type I IFN family best known for their antiviral activity. Most nucleated cells produce one or more Type I IFNs in response to viral infection. Secreted Type I IFN then induces viral protective responses in neighboring non-infected cells. Type I IFNs also enhance virus-induced apoptosis. Other IFN-α1 activities include enhancement of dendritic cell maturation and cytotoxic T cell activity. IFN-α1 binds to the IFN-αR1 and IFN-αR2 heterodimer. Intracellular signaling through the Jak/Stat pathway is best characterized. However, the PI3K, ERK, and p38 kinase pathways are also involved. The antiviral activities of the IFNs have led to their use in treating viral infections. Type I IFNs also appear to have an integral role in several autoimmune diseases.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Secreted

Uniprot	P01562
Database Links	HGNC:5417 OMIM:147578 KEGG:hsa:3439 STRING:9606.ENSP00000276927 UniGene:Hs.37026
Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes
Pathway	Jak-STAT signaling pathway PI3K-Akt signaling pathway Necroptosis Natural killer cell mediated cytotoxicity NOD-like receptor signaling pathway Toll-like receptor signaling pathway
Protein Families	Alpha/beta interferon family
Research Area	Cancer

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:2000

Tested Application

ELISA,WB;WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557119	CSB-PA365592KA01HU	100ul	$398		Add to Cart

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