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Home / Primary Antibodies / Polyclonal Antibodies

IFIT2 antibody

SKU : BHA10804131

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Mfr.No.	FNab04137
Alternative Names	CIG-42 ; G10P2 ; IFI54 ; ISG54
Background	IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Categories	Primary Antibodies
Clonality	polyclonal
Description	IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Host	Rabbit
Immunogen	interferon-induced protein with tetratricopeptide repeats 2
Isotype	IgG
Molecular Weight	50-55 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	cig42, G10P2, GARG 39, IFI 54, IFI 54K, IFI54, IFIT 2, IFIT2, ISG 54 K, ISG 54K, ISG54

Uniprot	P09913
Gene Id	3433
Research Area	Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF
Description	ELISA ; WB ; IHC ; IF
Tested Application	WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

Manual	FNab04137.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804131	FNab04137	100ug	$280		Add to Cart

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