Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).
Categories
Primary Antibodies
Clonality
monoclonal
Host
Mouse
Immunogen
iduronate 2-sulfatase
Isotype
IgG1
Molecular Weight
76 kDa, 55 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
IDS, iduronate 2 sulfatase, Idursulfase
Uniprot
P22304
Gene Id
3423
Clone No
2D2
Research Area
Cardiovascular, Metabolism
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)