Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity).
Host
Rabbit
Immunogen
inducible T-cell co-stimulator ligand
Isotype
IgG
Molecular Weight
28-35 kDa, 60-65 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
B7H2, B7RP1, ICOSL, KIAA0653
Uniprot
O75144
Gene Id
23308
Research Area
Immunology, Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)