ICAM-1 (CD54) is a 90-kDa transmembrane glycoprotein of the immunoglobulin superfamily and is critical for the firm attachment and transmigration of leukocytes out of blood vessels and into tissues (PMID: 19307690). ICAM-1 is expressed by several cell types, typically on endothelial cells and cells of the immune system, and its expression can be up-regulated by various stimuli, including TNF-alpha, INF-gamma, IL-1 and thrombin (PMID: 3086451; 9694714; 15979056). It is a ligand for LFA-1 and Mac-1, serves as a receptor for rhinovirus, and is one of several receptors used by Plasmodium falciparum (PMID: 2566624; 2538244; 2475784).
Categories
Primary Antibodies
Clonality
monoclonal
Host
Mouse
Immunogen
intercellular adhesion molecule 1
Isotype
IgG1
Molecular Weight
85-95 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
BB2, CD54, ICAM 1, ICAM1, ICAM-1, P3.58
Uniprot
P05362
Gene Id
3383
Clone No
7F11
Research Area
Stem Cells, Immunology, Cardiovascular
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)