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Home / Primary Antibodies / Polyclonal Antibodies

HUS1 antibody

SKU : BHA10804076

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Mfr.No.	FNab04082
Background	The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
Host	Rabbit
Immunogen	HUS1 checkpoint homolog (S. pombe)
Isotype	IgG
Molecular Weight	32 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	O60921
Gene Id	3364
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB
Description	ELISA ; IHC ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04082.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804076	FNab04082	100ug	$280		Add to Cart

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