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Home / Primary Antibodies / Polyclonal Antibodies

HNRNPL antibody

SKU : BHA10803950

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Mfr.No.	FNab03956
Alternative Names	HNRPL
Background	Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).
Host	Rabbit
Immunogen	heterogeneous nuclear ribonucleoprotein L
Isotype	IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	HNRPL

Uniprot	P14866
Gene Id	3191
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IHC
Description	ELISA ; WB ; IF ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab03956.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803950	FNab03956	100ug	$240		Add to Cart

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