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Home / Primary Antibodies / Polyclonal Antibodies

HMGCR antibody

SKU : BHA10803923

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Mfr.No.	FNab03929
Background	HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Host	Rabbit
Immunogen	3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Isotype	IgG
Molecular Weight	100 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	HMG CoA reductase, HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMDH

Uniprot	P04035
Gene Id	3156
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC
Description	ELISA ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab03929.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803923	FNab03929	100ug	$240		Add to Cart

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