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Home / Primary Antibodies / Polyclonal Antibodies

HMGB1 antibody

SKU : BHA10803918

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Mfr.No.	FNab03924
Alternative Names	DKFZp686A04236 ; highmobilitygroupbox1 ; Highmobilitygroupprotein1 ; HighmobilitygroupproteinB1 ; HMG1 ; HMG1 ; HMG3 ; HMGB1 ; SBP1
Background	This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.
Categories	Primary Antibodies
Clonality	polyclonal
Description	The HMG (high mobility group) proteins are nonhistone chromosomal proteins that is present in almost all eukaryotic cells, and it functions to stabilize NUCLEOSOME formation and acts as a transcription-factor-like protein that regulates the expression of several genes[PMID: 18160415]. Once injury, infection or other inflammatory stimuli, activated macrophages, mature dendritic cells and natural killer cells can secret HMGB1, which act as a crucial cytokine[PMID: 20163887]. HMGB1 also involved in V(D)J recombination by acting as a cofactor of the RAG complex, stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS)[PMID: 19360789 ]. Act as a Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. HMGB1 (high mobility group box 1) modulates gene expression in the nucleus, but certain immune cells secrete HMGB1 as an extracellular Alarmin to signal tissue damage.The nuclear HMGB1 relocalizes to the extracellular milieu in senescent human and mouse cells in culture and in vivo, which stimulated cytokine secretion through TLR-4 signaling (23649808).This antibody is a rabbit polyclonal antibody raised against full length HMGB1 of human origin.
Host	Rabbit
Immunogen	high-mobility group box 1
Isotype	IgG
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	DKFZp686A04236, high mobility group box 1, High mobility group protein 1, High mobility group protein B1, HMG 1, HMG1, HMG3, HMGB1, SBP 1

Uniprot	P09429
Gene Id	3146
Research Area	Epigenetics, Signal Transduction, Metabolism, Neuroscience
Weight	30kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:500-1:5000
IP	1:200-1:2000
IHC	1:50-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab03924.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803918	FNab03924	100ug	$240		Add to Cart

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