Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
Host
Rabbit
Immunogen
high-mobility group 20A
Isotype
IgG
Molecular Weight
40 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
HMGX1, HMGXB1
Uniprot
Q9NP66
Gene Id
10363
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)