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Home / Primary Antibodies / Monoclonal Antibodies

HLA class I (HLA-A) antibody

SKU : BHA10803890

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Mfr.No.	FNab03896
Background	HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
Categories	Primary Antibodies
Clonality	monoclonal
Host	Mouse
Immunogen	major histocompatibility complex, class I, A
Isotype	IgG2a
Molecular Weight	44 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	HLA A, HLA class I, HLA class I (HLA-A), HLA class I ABC, HLA-A, MHC class I antigen A*3

Uniprot	P04439/P30443
Gene Id	3105
Clone No	0D3
Research Area	Cell Division and Proliferation, Cardiovascular, Immunology, Cancer, Stem Cells, Signal Transduction

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, FC, IHC
Description	ELISA ; WB ; FC ; IHC
Tested Application	WB: 1:1000-1:8000; IHC: 1:20-1:200

Manual	FNab03896.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803890	FNab03896	100ug	$300		Add to Cart

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