Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes(PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination(PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration(Probable).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).
Host
Rabbit
Immunogen
histone cluster 1, H1t
Isotype
IgG
Molecular Weight
30 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
H1FT, H1T
Antigen
HIST1H1T
Uniprot
P22492
Gene Id
3010
Research Area
Developmental biology, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)