The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Description
May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
Host
Rabbit
Immunogen
HIRA interacting protein 3
Isotype
IgG
Molecular Weight
62 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Uniprot
Q9BW71
Gene Id
8479
Research Area
Stem Cells
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)