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Home / Primary Antibodies / Polyclonal Antibodies

HIF1a antibody

SKU : BHA10810295

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Mfr.No.	FNab10340
Background	Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-(AG)CGTG-3' within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Clonality	polyclonal
Host	Rabbit
Immunogen	hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
Immunogen Region	hypoXia inducible factor 1, alpha subunit(basic heliX-loop-heliX transcription factor)
Isotype	IgG
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:500-1:2000; IHC: 1:50-1:200
Subcellular Location	Cytoplasm, Nucleus
Synonyms	BHLHE78, MOP1, PASD8

Uniprot	Q16665
Gene Id	3091
Research Area	Epigenetics, Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Stem Cells, Neuroscience

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10340.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810295	FNab10340	100ug	$240		Add to Cart

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