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Home / Primary Antibodies / Polyclonal Antibodies

HEY1 antibody

SKU : BHA10803843

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Mfr.No.	FNab03849
Alternative Names	BHLHB31 ; CHF2 ; HERP2 ; HESR1 ; HRT1
Background	Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).
Host	Rabbit
Immunogen	hairy/enhancer-of-split related with YRPW motif 1
Isotype	IgG
Molecular Weight	33 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BHLHB31, CHF2, HERP2, HESR1, HRT1

Uniprot	Q9Y5J3
Gene Id	23462
Research Area	Developmental biology, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200

Manual	FNab03849.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803843	FNab03849	100ug	$240		Add to Cart

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