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Home / Primary Antibodies / Polyclonal Antibodies

HER2/ErbB2 antibody

SKU : BHA10803827

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Mfr.No.	FNab03833
Alternative Names	CD340 ; ERBB2 ; HER2 ; HER2/neu ; HER2 ; MLN19 ; MLN19 ; NEU ; NGL ; p185 ; p185erbB2
Background	HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185-kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form.
Categories	Primary Antibodies
Clonality	polyclonal
Description	HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185-kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form.
Host	Rabbit
Immunogen	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog(avian)
Isotype	IgG
Molecular Weight	185 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1

Uniprot	P04626
Gene Id	2064
Research Area	Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells
Weight	180kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, FC, IP

Description

ELISA ; WB ; IHC ; FC ; IP

Dilution

WB	1:1000-1:10000

Tested Application

WB: 1:1000-1:10000; IP: 1:200-1:2000; IHC: 1:50-1:200

Manual	FNab03833.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803827	FNab03833	100ug	$260		Add to Cart

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