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Home / Primary Antibodies / Polyclonal Antibodies

HDAC8 antibody

SKU : BHA10803799

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Mfr.No.	FNab03805
Alternative Names	HDACL1
Background	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
Host	Rabbit
Immunogen	histone deacetylase 8
Isotype	IgG
Molecular Weight	43 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	HDACL1

Uniprot	Q9BY41
Gene Id	55869
Research Area	Epigenetics, Immunology, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab03805.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803799	FNab03805	100ug	$240		Add to Cart

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