Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
histone deacetylase 6
Isotype
IgG
Molecular Weight
178 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
HD6, HDAC6, histone deacetylase 6, JM21, KIAA0901
Uniprot
Q9UBN7
Gene Id
10013
Research Area
Epigenetics, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)