This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
Clonality
polyclonal
Host
Rabbit
Immunogen
histone deacetylase 2
Immunogen Region
histone deacetylase 2
Isotype
IgG
Molecular Weight
56 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Synonyms
HD2, HDAC2, histone deacetylase 2, RPD3, YAF1
Uniprot
Q92769
Gene Id
3066
Research Area
Epigenetics, Cardiovascular, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09976.pdf" target="_blank">Data Sheet</ a>