Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine(PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure(By similarity). Plays an important role in the down-regulation of neuronal excitability(By similarity). Contributes to the generation of inhibitory postsynaptic currents(By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels(By similarity). Plays a role in cellular responses to ethanol(By similarity).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).
Host
Rabbit
Immunogen
glycine receptor, alpha 3
Isotype
IgG
Molecular Weight
54kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Uniprot
O75311
Gene Id
8001
Research Area
Developmental biology, Signal Transduction, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)