Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine(PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine(PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents(PubMed:25445488). Plays a role in cellular responses to ethanol(PubMed:23895467).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).
Host
Rabbit
Immunogen
glycine receptor, alpha 2
Isotype
IgG
Molecular Weight
48 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
GLR, GLRA2, glycine receptor, alpha 2
Uniprot
P23416
Gene Id
2742
Research Area
Developmental biology, Signal Transduction, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)