As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents(PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP(PubMed:20180847).
Categories
Primary Antibodies
Clonality
polyclonal
Description
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).
Host
Rabbit
Immunogen
guanylate binding protein 5
Isotype
IgG
Molecular Weight
65 kDa, 55 kDa
Reactivity
Human
Regulatory
RUO
Antigen
GBP5
Uniprot
Q96PP8
Gene Id
115362
Research Area
Immunology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)