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Home / Primary Antibodies / Polyclonal Antibodies

GAS6 antibody

SKU : BHA10803346

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Mfr.No.	FNab03352
Alternative Names	AXLLG
Background	This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).
Host	Rabbit
Immunogen	growth arrest-specific 6
Isotype	IgG
Molecular Weight	80 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	AXLLG

Uniprot	Q14393
Gene Id	2621
Research Area	Stem Cells, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB
Description	ELISA ; IHC ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab03352.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803346	FNab03352	100ug	$280		Add to Cart

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