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Home / Primary Antibodies / Polyclonal Antibodies

GADD34 antibody

SKU : BHA10803287

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Mfr.No.	FNab03293
Background	GADD34, also named PPP1R15A, belongs to the PPP1R15 family. GADD34 can be triggered as a direct target of activating transcription factor4(ATF4) under ER stress, it plays a pivotal role in the recovery of cells from shut-down of translation induced by ER stress. It recruits the serine/threonine-protein phosphatase(PP1) to dephosphorylate the translation initiation factor eIF2alpha, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. GADD34 down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 via PP1. It may also promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Starvation-induced expression of GADD34 reduced mTOR activity and induced autophagy in wild-type mice, but not in GADD34 KO mice. Molecular weight of GADD34 appears to be about 100 kDa which was confirmed in GADD34 KO mice and drug treated cells, despite the predicated MW of 73 kDa, and this antibody primarily recongize the 100 kDa band.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	protein phosphatase 1, regulatory(inhibitor) subunit 15A
Isotype	IgG
Molecular Weight	100 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	GADD34, growth arrest and DNA damage-inducible protein 34, PPP1R15A

Uniprot	O75807
Research Area	Epigenetics

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF
Description	ELISA ; WB ; IHC ; IF
Tested Application	WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

Manual	FNab03293.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803287	FNab03293	100ug	$260		Add to Cart

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