Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements(IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells(ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Host
Rabbit
Immunogen
forkhead box O4
Isotype
IgG
Molecular Weight
45-48kd
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
AFX, AFX1, MLLT7
Uniprot
P98177
Gene Id
4303
Research Area
Epigenetics, Developmental biology, Signal Transduction, Metabolism, Immunology, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)