Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle(PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation(By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm(By similarity). Is required for morphogenesis and differentiation of the anterior segment of the eye(By similarity).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Is required for morphogenesis and differentiation of the anterior segment of the eye (By similarity).
Host
Rabbit
Immunogen
forkhead box E3
Isotype
IgG
Molecular Weight
30-35kd
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
FKHL12, FREAC8
Uniprot
Q13461
Gene Id
2301
Research Area
Developmental biology, Signal Transduction, Metabolism, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)