Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
Host
Rabbit
Immunogen
forkhead box C1
Isotype
IgG
Molecular Weight
70 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
FKHL7, FREAC3
Uniprot
Q12948
Gene Id
2296
Research Area
Epigenetics, Developmental biology, Signal Transduction, Metabolism, Stem Cells, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)