This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Host
Rabbit
Immunogen
Friend leukemia virus integration 1
Isotype
IgG
Molecular Weight
43 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
EWSR2, FLI1, Proto oncogene Fli 1, SIC 1, Transcription factor ERGB
Uniprot
Q01543
Gene Id
2313
Research Area
Epigenetics, Developmental biology, Signal Transduction, Metabolism, Cancer, Immunology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)