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Home / Primary Antibodies / Polyclonal Antibodies

FKBP6 antibody

SKU : BHA10803140

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Mfr.No.	FNab03146
Alternative Names	FKBP36
Background	The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Host	Rabbit
Immunogen	FK506 binding protein 6, 36kDa
Isotype	IgG
Molecular Weight	37 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	FKBP36

Uniprot	O75344
Gene Id	8468
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

Manual	FNab03146.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803140	FNab03146	100ug	$240		Add to Cart

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