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Home / Primary Antibodies / Polyclonal Antibodies

FCN1 antibody

SKU : BHA10803054

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Mfr.No.	FNab03060
Alternative Names	FCNM
Background	The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Host	Rabbit
Immunogen	ficolin (collagen/fibrinogen domain containing) 1
Isotype	IgG
Molecular Weight	38 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	FCNM

Uniprot	O00602
Gene Id	2219
Research Area	Cancer, Immunology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab03060.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803054	FNab03060	100ug	$280		Add to Cart

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