Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome(APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
Host
Rabbit
Immunogen
F-box protein 5
Isotype
IgG
Molecular Weight
56 kDa, 45 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
EMI1, FBX5
Uniprot
Q9UKT4
Gene Id
26271
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)