Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin(ACTN2) and filamin-C(FLNC), essential for maintenance of normal contractile function.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
Host
Rabbit
Immunogen
F-box protein 22
Isotype
IgG
Molecular Weight
45 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
FBX22
Uniprot
Q8NEZ5
Gene Id
26263
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)