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Home / Primary Antibodies / Polyclonal Antibodies

FAS/CD95 antibody

SKU : BHA10803010

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Mfr.No.	FNab03016
Background	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	Fas (TNF receptor superfamily, member 6)
Isotype	IgG
Molecular Weight	Refer to figures
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6

Uniprot	P25445
Gene Id	355
Research Area	Cancer, Immunology, Cardiovascular, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP, FC
Description	ELISA ; WB ; IHC ; IP ; FC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab03016.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803010	FNab03016	100ug	$280		Add to Cart

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