ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.
Categories
Primary Antibodies
Clonality
polyclonal
Description
ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.
Host
Rabbit
Immunogen
Fanconi anemia, complementation group M
Isotype
IgG
Molecular Weight
250 kDa, 232 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
KIAA1596
Uniprot
Q8IYD8
Gene Id
57697
Research Area
Epigenetics, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)