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Home / Primary Antibodies / Polyclonal Antibodies

EXO1 antibody

SKU : BHA10802885

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Mfr.No.	FNab02891
Alternative Names	EXOI ; HEX1
Background	This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.
Categories	Primary Antibodies
Clonality	polyclonal
Description	5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Host	Rabbit
Immunogen	exonuclease 1
Isotype	IgG
Molecular Weight	94 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	EXOI, HEX1

Uniprot	Q9UQ84
Gene Id	9156
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab02891.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802885	FNab02891	100ug	$280		Add to Cart

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