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Home / Primary Antibodies / Polyclonal Antibodies

ESR2 antibody

SKU : BHA10802860

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Mfr.No.	FNab02866
Alternative Names	ESTRB ; NR3A2
Background	This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Host	Rabbit
Immunogen	estrogen receptor 2 (ER beta)
Isotype	IgG
Molecular Weight	55-60 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ESTRB, NR3A2

Uniprot	Q92731
Gene Id	2100
Research Area	Developmental biology, Cell Division and Proliferation, Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB
Description	ELISA ; IHC ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab02866.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802860	FNab02866	100ug	$240		Add to Cart

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