Rabbit Anti-Human ErbB4 Polyclonal

Mfr.No.	SPC-1139, SPC-1139D, SPC-1139D-A390, SPC-1139D-A488, SPC-1139D-A594, SPC-1139D-BI, SPC-1139D-FITC
Immunogen Species	Human
Alternative Names	Avian erythroblastic leukemia viral oncogene homolog 4 antibody, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody, E4ICD antibody, EC 2.7.10.1 antibody, Erbb4 antibody, ERBB4 intracellular domain antibody, ERBB4_HUMAN antibody, HER 4 antibody, human epidermal growth factor receptor 4 antibody, Mer4 antibody, Proto-oncogene-like protein c-ErbB-4 antibody, Receptor protein tyrosine kinase erbB 4 precursor antibody, Tyrosine kinase type cell surface receptor HER4 antibody , v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody, VERBB2 antibody
Categories	Antibodies
Cellular Localization	Cell membrane
Certificate Of Analysis	A 1:250 dilution of SPC-1139 was sufficient for detection of ErbB4 in 10 ug of mouse brain lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human ErbB4 Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide of human ErbB4 (AA42-56), Homo Sapiens (Human)
Immunogen Region	Synthetic peptide of human ErbB4 (AA42-56)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Human
Tissue Specificity	Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.

Swissprot	Q15303
Accession Number	NP_005226
Gene Id	2066
Target	ErbB4
Research Area	Cell Signaling, Protein Phosphorylation, Tyrosine Kinases, Receptor Tyrosine Kinases, Growth Factors, EGF, Cancer, Tumor Biomarkers, Oncoproteins, Growth Factor Receptors

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.
Scientific Background	ErbB4 is an RTK involved in cell growth and differentiation. Ligands are neuregulins and not EGF. Donwregulation has been described in bladder cancer to correlated with oncogensis, but upregulation of ErbB4 is noted in lung cancer. Its mutation pattern in human tumours is very characteristic of a tumour suppressor protein.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 147 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11915318-1	SPC-1139D	Unconjugated	100 ul	$331	Add to Cart
BHA11915318-2	SPC-1139D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11915318-3	SPC-1139D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11915318-4	SPC-1139D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11915318-5	SPC-1139D-BI	Biotin	100 ul	$380	Add to Cart
BHA11915318-6	SPC-1139D-FITC	FITC	100 ul	$375	Add to Cart

ErbB4 Antibody - SPC-1139

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