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Home / Primary Antibodies / Polyclonal Antibodies

EPOR antibody

SKU : BHA10802810

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Mfr.No.	FNab02816
Background	This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
Host	Rabbit
Immunogen	erythropoietin receptor
Isotype	IgG
Molecular Weight	53 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	EPO R, EPOR, erythropoietin receptor

Uniprot	P19235
Gene Id	2057
Research Area	stem cells, Signal Transduction, Immunology, Cardiovascular, Cancer

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IP, WB, FC
Description	ELISA ; IP ; WB ; FC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab02816.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802810	FNab02816	100ug	$280		Add to Cart

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