Epithelial cell adhesion molecule(EpCAM, CD326) is a type I transmembrane glycoprotein that functions as a homophilic, epithelial-specific intercellular cell-adhesion molecule. In addition to cell adhesion, EpCAM is also involved in cellular signaling, cell migration, proliferation, and differentiation. EpCAM is highly expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic marker for a variety of carcinomas, and has become a therapeutic target.(PMID: 20837599; 19249674; 21576002; 22647938)
Clonality
monoclonal
Host
Mouse
Immunogen
epithelial cell adhesion molecule
Immunogen Region
epithelial cell adhesion molecule
Isotype
IgG1
Molecular Weight
36 kDa
Reactivity
Human
Recommended Dilution
WB: 1:1000-1:10000; IHC: 1:50-1:500
Synonyms
GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
Uniprot
P16422
Clone No
3C8
Research Area
Stem Cells, Immunology, Signal Transduction, Cancer
Form
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:1000-1:10000; IHC: 1:50-1:500
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09783.pdf" target="_blank">Data Sheet</ a>