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Home / Primary Antibodies / Polyclonal Antibodies

EIF3M antibody

SKU : BHA10802708

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Mfr.No.	FNab02714
Alternative Names	HFLB5 ; PCID1
Background	This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).
Host	Rabbit
Immunogen	eukaryotic translation initiation factor 3, subunit M
Isotype	IgG
Molecular Weight	40 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	HFLB5, PCID1

Uniprot	Q7L2H7
Gene Id	10480
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab02714.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802708	FNab02714	100ug	$240		Add to Cart

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