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Home / Primary Antibodies / Polyclonal Antibodies

EIF2AK1 antibody

SKU : BHA10810404

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Mfr.No.	FNab10450
Background	Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells(RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions(By similarity).
Clonality	polyclonal
Host	Rabbit
Immunogen	eukaryotic translation initiation factor 2-alpha kinase 1
Immunogen Region	eukaryotic translation initiation factor 2-alpha kinase 1
Isotype	IgG
Molecular Weight	60-71 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Synonyms	EIF2AK1, HCR, HRI, eukaryotic translation initiation factor 2-alpha kinase 1

Uniprot	Q9BQI3
Gene Id	27102
Research Area	Immunology, Metabolism, Neuroscience

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10450.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810404	FNab10450	100ug	$240		Add to Cart

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