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Home / Primary Antibodies / Polyclonal Antibodies

EHD1 antibody

SKU : BHA10802668

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Mfr.No.	FNab02674
Alternative Names	PAST
Background	ATP-and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes(PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes(PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth(By similarity). Plays a role in myoblast fusion(By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing(By similarity). Plays a role in the formation of the ciliary vesicle(CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles(DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis(PubMed:25686250).
Categories	Primary Antibodies
Clonality	polyclonal
Description	ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8- dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).
Host	Rabbit
Immunogen	EH-domain containing 1
Isotype	IgG
Molecular Weight	61 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	PAST,

Uniprot	Q9H4M9
Gene Id	10938
Research Area	Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF
Description	ELISA ; WB ; IF
Tested Application	WB: 1:500-1:2000; IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802668	FNab02674	100ug	$260		Add to Cart

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