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Home / Primary Antibodies / Polyclonal Antibodies

EGFR antibody

SKU : BHA10802662

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Mfr.No.	FNab02668
Alternative Names	ERBB ; ERBB1 ; HER1
Background	The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
Host	Rabbit
Immunogen	epidermal growth factor receptor
Isotype	IgG
Molecular Weight	180 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ERBB, ERBB1, HER1

Uniprot	P00533
Gene Id	1956
Research Area	Signal Transduction, Metabolism, Cardiovascular, Cancer, Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP, IF
Description	ELISA ; WB ; IHC ; IP ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab02668.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802662	FNab02668	100ug	$280		Add to Cart

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