The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
Clonality
monoclonal
Host
Mouse
Immunogen
epidermal growth factor receptor
Immunogen Region
epidermal growth factor receptor
Isotype
IgG1
Molecular Weight
140-160 kDa
Reactivity
Human
Recommended Dilution
WB: 1:2000 - 1:10000; IHC: 1:100 - 1:1000
Synonyms
EGFR, ERBB, ERBB1, HER1, mENA, PIG61, Proto oncogene c ErbB 1
Uniprot
P00533
Gene Id
1956
Clone No
2C9
Research Area
Signal Transduction, Immunology, Cancer
Form
liquid
Purification
protein A+G purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:2000 - 1:10000; IHC: 1:100 - 1:1000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10146.pdf" target="_blank">Data Sheet</ a>