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Home / Primary Antibodies / Polyclonal Antibodies

E-cadherin antibody

SKU : BHA10802612

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Mfr.No.	FNab02618
Background	This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	cadherin 1, type 1, E-cadherin (epithelial)
Isotype	IgG
Molecular Weight	130 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin

Uniprot	P12830
Gene Id	999
Research Area	Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB, IP, FC, IF
Description	ELISA ; IHC ; WB ; IP ; FC ; IF
Tested Application	WB: 1:500 - 1:1000; IHC: 1:50 - 1:200

Manual	FNab02618.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802612	FNab02618	100ug	$240		Add to Cart

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