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Home / Primary Antibodies / Polyclonal Antibodies

DR1 antibody

SKU : BHA10802521

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Mfr.No.	FNab02527
Background	This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Categories	Primary Antibodies
Clonality	polyclonal
Description	The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Host	Rabbit
Immunogen	down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Isotype	IgG
Molecular Weight	19 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	Q01658
Gene Id	1810
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab02527.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802521	FNab02527	100ug	$260		Add to Cart

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