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Home / Primary Antibodies / Polyclonal Antibodies

DOCK7 antibody

SKU : BHA10802491

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Mfr.No.	FNab02497
Alternative Names	KIAA1771
Background	Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).
Host	Rabbit
Immunogen	dedicator of cytokinesis 7
Isotype	IgG
Molecular Weight	240 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	dedicator of cytokinesis 7, DOCK7, KIAA1771, ZIR2

Uniprot	Q96N67
Gene Id	85440
Research Area	Developmental biology, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:200-1:1000; IP: 1:500-1:1000

Manual	FNab02497.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802491	FNab02497	100ug	$240		Add to Cart

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