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Home / Primary Antibodies / Polyclonal Antibodies

DNMT3A antibody

SKU : BHA10802479

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Mfr.No.	FNab02485
Background	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation pattes during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in pateal and mateal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3(H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation pattes during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in pateal and mateal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Host	Rabbit
Immunogen	DNA(cytosine-5-)-methyltransferase 3 alpha
Isotype	IgG
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Antigen	DNMT3A
Uniprot	Q9Y6K1
Gene Id	1788
Research Area	Epigenetics, Developmental biology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500-1:2000; IP: 1:200-1:2000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802479	FNab02485	100ug	$240		Add to Cart

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